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Dear Dr. Vinny,
If a bottle of wine has a twist-off cap, is it OK to store it upright?
The primary reason that wine bottles sealed with natural corks are stored on their sides is to keep the cork moist, so that it doesn't dry out and shrink. Screwcaps don't need to be kept moist to remain effective, so yes, it's OK to store wine with a twist-off cap upright. But you should still follow the same general principles of good wine storage, including protecting the wine from light and vibration and keeping it at a steady, cool temperature.
Since I like to store all of my wine together, I keep the screwcaps on their sides in the racks with the rest of my bottles.
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