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Dear Dr. Vinny,
Regarding wines with screw-top closures: Is it better to store these wines upright or on their sides, or does it not matter?
—Steve G., Williamsburg, Va.
It doesn't matter. If you have a bottle with a cork, you want to keep the cork from drying out and getting all crumbly, which is not only bad for your wine, it's bad for your blood pressure when you're trying to uncork it.
Since twist-offs don't have that same threat, you can store them facing any way you want—as long as you avoid light, vibration, and temperature fluctuation, which will still damage your wine, no matter how it's closed.
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